Alonso Alvarez de Piñeda, a Spanish explorer, maps the Texas coast and travels through the Rio Grande Valley, claiming the land for Spain.
Fray Zamora, a member of the Narváez Expedition into Mexico, is credited with establishing the town of Peñitas.
Three Spanish ships carrying several Domincan priests are wrecked off the Texas coast.
Spain returns to the Rio Grande Valley. Jose de Escandón maps the region and sends Franciscan priests and many colonists from Mexico.
Fray Juan Bautista established a settlement for native converts near what is now Rio Grande City.
Father José Gutierrez and his parishioners build a stone church called San Agustín de Laredo, the first parish church in South Texas.
Padre José Nicolás Balli establishes the Nuestra Señora del Refugio Mission on what would come to be called “Padre Island” in his honor.
Texas is annexed to the United States. The Rio Grande Valley becomes the center of a border dispute between the United States and Mexico, leading to the Mexican-American War.
The Mexican-American War ends with the Treaty of Guadalupe-Hidalgo, placing the US-Mexico border along the Rio Grande.